Angiogenic synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in an in vitro quantitative microcarrier-based three-dimensional fibrin angiogenesis system

Figure 4 Dose responses of bFGF and VEGF on angiogenesis. Both bFGF and VEGF exhibited dose-dependent angiogenic effects in the range from 10 to 40 ng/mL. At d 1, 10 ng/mL of bFGF and VEGF induced angiogenesis with an ALS of 32.13 ± 16.6 µm and 43.75 ± 27.92 µm, respectively, which were significantly higher than that of the control (5.88 ± 4.45 µm, P < 0.01). With the concentration increasing, the difference became more significant.