Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1

Table 3 The pituitary-gonadal axis (on d 15) in the three experimental groups

	Healthy control rats (CO, n = 12)	Untreated cirrhotic rats (CI, n = 12)	IGF-1-treated cirrhotic rats (CI + IGF, n = 12)
Total testosterone (ng/dL)	62 ± 13	77 ± 17	64 ± 7
Free testosterone (pg/mL)	0.36 ± 0.09	0.36 ± 0.10	0.41 ± 0.05
Estradiol (pg/mL)	31 ± 2	33 ± 2	29 ± 1
Estradiol/Total testosterone	0.5 ± 0.1	0.5 ± 0.1	0.6 ± 0.1
LH (ng/mL)	4.8 ± 0.6	6.0 ± 0.5	3.8 ± 0.7d
FSH (ng/mL)	22 ± 8	27 ± 1f	26 ± 4b

^bP < 0.01 CI + IGF vs CO group;

^dP < 0.01 CI + IGF vs CI group;

^fP < 0.001 CI vs CO group.