Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis

Table 5 Effect of mild irritants and/or 50% ethanol on leukotriene C₄ (LTC₄) level in gastric mucosa of normal and gastritis rats

	LTC4 level (pg/mg protein)
	H2O	200 mL/L EtOH	50 g/L NaCl	0.3 mol/L HCl
Basal normal	13.33 ± 3.08	5.77 ± 0.86a	4.19 ± 0.67a	4.28 ± 0.81a
500 mL/L EtOH normal	29.28 ± 5.46c	10.01 ± 1.87b	9.15 ± 3.05b	8.17 ± 2.42b
Basal gastritis	35.08 ± 6.28e	17.05 ± 4.22ae	12.88 ± 3.68ae	14.86 ± 3.60ae
500 mL/L EtOH gastritis	43.84 ± 3.79	18.86 ± 4.66b	17.70 ± 3.06d	21.28 ± 6.33a

Values are mean ± SE (n = 6),

^aP < 0.05,

^bP < 0.01,

^dP < 0.001 vs corresponding H₂O group without mild irritant.

^cP < 0.05 vs corresponding group without 500 mL/L EtOH treatment (Basal).

^eP < 0.05 vs corresponding group without gastritis (Normal).