Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis

Table 3 Effect of mild irritants and/or 500 mL/L ethanol on constitutive and inducible nitric oxide synthase activity in gastric mucosa of normal and gastritis rats

	Nitric oxide synthase activity (cpm/min/mg protein)
	H2O		200 mL/L EtOH		50 g/L NaCl		0.3 mol/L HCl
	Constitutive	Inducible	Constitutive	Inducible	Constitutive	Inducible	Constitutive	Inducible
Basal normal	266.01 ± 22.10	96.97 ± 12.72	768.98 ± 93.17b	107.66 ± 17.17	734.68 ± 74.67b	84.13 ± 19.26	328.77 ± 48.23	97.52 ± 16.12
500 mL/L EtOH normal	132.18 ± 16.49d	106.55 ± 13.19	326.54 ± 33.43a,h	143.51 ± 15.71	282.67 ± 23.86a,d	109.67 ± 12.32a	160.86 ± 25.07	137.24 ± 16.13
Basal gastritis	31.56 ± 7.20f	856.58 ± 93.82f	31.13 ± 10.47f	746.05 ± 94.07f	41.26 ± 11.64f	649.89 ± 81.83f	22.27 ± 8.01f	949.87 ± 106.22f
500 mL/L EtOH gastritis	56.21 ± 8.64j	972.29 ± 123.73f	39.12 ± 3.09f	888.88 ± 129.36f	42.72 ± 10.29f	853.36 ± 103.64f	49.82 ± 10.58j	875.24 ± 122.44f

Values are mean ± SE (n = 6),

^bP < 0.001 vs corresponding H₂O group without mild irritant.

^aP < 0.05,

^hP < 0.01,

^dP < 0.001 vs corresponding group without 500 mL/L EtOH treatment (Basal).

^jP < 0.01,

^fP < 0.001 vs corresponding group without gastritis (Normal).