Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis

Table 2 Effect of mild irritants on 500 mL/L ethanol-induced histological damage in gastric mucosa of normal and gastritis rats, and modulation of protective action of 200 mL/L ethanol by pretreatment with L-NAME

Treatment	Histological damage (% total mucosal thickness)
	Normal				Gastritis
	Total	Type I	Type II	Type III	Total	Type I	Type II	Type III
H2O (Control)	70.80 ± 1.26	16.23 ± 1.07	21.92 ± 1.01	31.36 ± 1.67	91.13 ± 4.31f	14.99 ± 1.14	27.37 ± 1.83e	48.77 ± 3.69f
200 mL/L EtOH	59.61 ± 2.04b	11.12 ± 0.97h	15.27 ± 1.10h	33.20 ± 1.80	92.23 ± 3.89j	14.17 ± 1.26	25.06 ± 1.77j	53.00 ± 3.16j
50 g/L NaCl	73.16 ± 1.82	15.37 ± 1.26	22.64 ± 1.54	35.15 ± 2.07	90.73 ± 3.15f	12.11 ± 1.02	28.33 ± 1.60e	50.29 ± 3.40f
0.3 mmol/L HCl	66.37 ± 2.21	18.20 ± 1.55	20.01 ± 1.98	28.16 ± 3.04	89.83 ± 3.71f	13.72 ± 1.33	25.69 ± 1.52e	50.40 ± 2.56j
L-NAME + H2O	74.2 ± 1.96	16.41 ± 1.72	21.19 ± 1.70	36.62 ± 3.21	94.27 ± 3.06f	15.21 ± 1.31	29.61 ± 1.97f	49.42 ± 3.90e
L-NAME + 200 mL/L EtOH	69.75 ± 2.11d	15.55 ± 1.41a	20.48 ± 1.88c	33.71 ± 2.86	95.10 ± 3.62f	13.78 ± 1.56	27.49 ± 1.81e	53.82 ± 4.11f

Values are mean ± SE (n = 6),

^hP < 0.01,

^bP < 0.001 vs corresponding H₂O group without mild irritant.

^aP < 0.05,

^dP < 0.01 vs corresponding group without drug pretreatment.

^eP < 0.05,

^fP < 0.01,

^jP < 0.001 vs corresponding group without gastritis (Normal).