Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis

Table 1 Effect of mild irritants on 500 mL/L ethanol-induced macroscopic lesion formation in gastric mucosa of normal and gastritis rats, and modulation by pretreatment with L-NAME

Pretreatment	Macroscopic lesion areas (mm2)
	Normal	Gastritis
H2O (Control)	41.17 ± 7.85	134.17 ± 19.23d
200 mL/L EtOH	2.00 ± 0.93b	31.33 ± 5.96bf
50 g/L NaCl	0 ± 0b	15.00 ± 3.80bf
0.3 mol/L HCl	0 ± 0b	124.33 ± 20.60f
L-NAME + H2O	42.50 ± 10.65	125.40 ± 17.75f
L-NAME + 200 mL/L EtOH	32.33 ± 9.95a	98.83 ± 7.22hf
L-NAME + 50 g/L NaCl	0 ± 0b	32.25 ± 7.49bf
L-NAME + 0.3 mol/L HCl	0 ± 0b	104.25 ± 12.20h

Values are mean ± SE (n = 6),

^bP < 0.001 vs corresponding H₂O group without mild irritant.

^aP < 0.05,

^fP < 0.001vs corresponding group without drug pretreatment.

^dP < 0.01,

^hP < 0.001 vs corresponding group without gastritis (Normal).