Pathophysiological significance of a reaction in mouse gastrointestinal tract associated with delayed-type hypersensitivity

Figure 3 The pathological change of colon by DNCB enema in sensitized mice. A1: control 600 mL/L ethanol, normal histological structures. A2: DTH_(-), only slight mucosa congestion. B: 1 g/L DNCB, hyperemia, infiltration of chronic inflammatory. cells, decrease of the number of goblet cell in colon mucosa. C: 2 g/L DNCB, superficial erosion, chronic inflammation of colon mucosa. D: 4 g/L DNCB, atrophic changes of colon mucosa with chronic inflammation. E: 4 g/L DNCB, ulcer and hemorrhage in colon mucosa (HE, ×200).