HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding

doi:10.3748/wjg.v10.i15.2223

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Aug 1, 2004 (publication date) through Nov 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Aug 1, 2004; 10(15): 2223-2227
Published online Aug 1, 2004. doi: 10.3748/wjg.v10.i15.2223

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Figure 1 HCVNS5A inhibits p53 binding to its specific DNA probe. Lane 1: Negative control; Lane 2: Transfected with pC53-NS3 only; Lane 3: Transfected with pCNS5A only; Lanes 4 -6: Co-transfected with pC53-NS3 (1 μg) and different dose of pCNS5A; Lanes 7-8: Transfected with pC53-NS3, and antip53, antiNS5A anti-bodies were added to the reaction mixture individually.

Citation: Gong GZ, Jiang YF, He Y, Lai LY, Zhu YH, Su XS. HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding. World J Gastroenterol 2004; 10(15): 2223-2227
URL: https://www.wjgnet.com/1007-9327/full/v10/i15/2223.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i15.2223