HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding

Table 2 HCV NS5A inhibits exogenous p53 transactivation on p21 promoter

Group	Relative luciferase activity	F	P
pwwp-luc (1 µg)	0.47 × 105ab	24.23	< 0.01
+pC53-NS3 (1 µg)	5.63 × 105b
+pCNS5A (0.5 µg)	1.61 × 105
+pCNS5A (1.0 µg)	0.69 × 105
pwwp-mut-luc (1 µg)	0.45 × 105a	0.69	> 0.05
+pC53-NS3 (1 µg)	0.50 × 105
+pCNS5A (0.5 µg)	0.43 × 105
+pCNS5A (1.0 µg)	0.48 × 105

^at = 1.16, P > 0.05; ^bt = 10.12, P < 0.01.