Therapeutic polypeptides based on HBV core 18-27 epitope can induce CD8+ CTL-mediated cytotoxicity in HLA-A2+ human PBMCs

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Jul 1, 2004 (publication date) through Nov 30, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Jul 1, 2004; 10(13): 1902-1906
Published online Jul 1, 2004. doi: 10.3748/wjg.v10.i13.1902

Table 2 Peptide-specific CD₈⁺ T cells induced expressed as ISCs/10⁶ PBMCs (mean ± SD, n = 27)

	ISCs /10⁶ PBMCs
	Peptide1^d	Peptide2^d	Peptide3^d^b	Irrelevant control	Negative controls
PBMCs from healthy donors	1667.5 ± 231.3	4133.7 ± 416.6	9200.5 ± 1638.1	1315.5 ± 321.3	233.3 ± 208.6
PBMCs from chronic hepatitis patients	1420.0 ± 253.5	3915.7 ± 685.9	8966.7 ± 1435.3	1230.0 ± 355.2	245.1 ± 223.3

^bP < 0.01 vs peptide1 and 2 groups,

^dP < 0.01 vs negative control.

Citation: Shi TD, Wu YZ, Jia ZC, Zou LY, Zhou W. Therapeutic polypeptides based on HBV core 18-27 epitope can induce CD₈⁺ CTL-mediated cytotoxicity in HLA-A2⁺ human PBMCs. World J Gastroenterol 2004; 10(13): 1902-1906
URL: https://www.wjgnet.com/1007-9327/full/v10/i13/1902.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i13.1902