Differential Cl- and HCO3- mediated anion secretion by different colonic cell types in response to tetromethylpyrazine

Figure 5 TMP-induced anion secretions in rat colonic mucosa. Representative I_SC recording values are mean ± SE; ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. A: 1 mmol/L; B: 5 mmol/L of TMP added basolaterally in normal K-HS; C: Comparison of TMP (1 and 5 mmol/L)-induced I_SC obtained in normal and Cl^--free as well as both of Cl^- and HCO₃^- -free solutions; D: Comparison of TMP (1 and 5 mmol/L)-induced I_SC obtained in basolateral pretreatment of colonic mucosa with bumetanide (100 µmol/L) and DIDS (100 µmol/L).