Differential Cl- and HCO3- mediated anion secretion by different colonic cell types in response to tetromethylpyrazine

Figure 3 HCO₃^- dependence of TMP-induced I_SC increase in Caco-2 cells. Representative I_SC recording with arrows indicating TMP (5 mmol/L) added basolaterally, which was abolished by apical application of glybenclamide. Values are mean ± SE; ^aP < 0.05, ^bP < 0.01 and ^cP < 0.001. A: Normal; B: Cl-free; C: K-HS, comparison of TMP-induced total charges transferred in normal and Cl^--free K-HS.