Differential Cl- and HCO3- mediated anion secretion by different colonic cell types in response to tetromethylpyrazine

Figure 1 TMP-induced I_SC response in T84 and Caco-2 cell lines. The concentration-response curve for TMP-induced response in T84 and Caco-2 cells, and each datum was obtained from at least 4 individual experiments. A: Values are mean ± SE of maximal I_SC increase; B: Representative I_SC recordings in response to apical addition of TMP (1 mmol/L) in T84 cells; C: Basolateral application of TMP (5 mmol/L) in Caco-2 cells.