Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma

Table 1 Correlation between methylation of Syk promoter region and clinicopathologic factors (n)

Factor	Frequency of Syk promoter region methylation	P
Gender
Male	14/38
Female	7/23	0.26
Tumor size
< 3cm	8/26
3	13/35	0.61
Depth of invasion
Mucosa and submucosa	2/9
Muscle and subserosa	7/29
Serosa	12/23	0.075
Lymph node metastasis
Present	17/31
Absent	4/30	0.0016
Stage
I-II	6/25
III-IV	15/36	0.24
Tumor location
Lower third	6/15
Middle third	11/35
Upper third	4/11	0.83