Inhibition of Fas/FasL mRNA expression and TNF-α release in concanavalin A-induced liver injury in mice by bicyclol

Table 2 Effect of bicyclol on liver histology by evaluation the degree of liver injury 12 h after Con A injection

Group	Grade of liver injury
	0	1	2	3
Normal (n = 7)	7	0	0	0
Con A alone (n = 7)	0	0	0	7
ConA+bicyclol 200 mg/kg (n = 8)	3	2	1	2
ConA+bicyclol 100 mg/kg (n = 7)	1	2	3	1

Histological degree of liver injury is classified according to the area of coagulative necrosis in hepatic lobules as follows: grade 0, no coagulative necrosis; grade 1, coagulative necrosis area < 10%; grade 2, coagulative necrosis area between 10% and 25%; grade 3, coagulative necrosis area > 25%.