Time- and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid

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Jun 15, 2004 (publication date) through Dec 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 2004; 10(12): 1769-1774
Published online Jun 15, 2004. doi: 10.3748/wjg.v10.i12.1769

Table 1 Dissolution conditions of 5-ASA coated pellets

pH	λ_max (nm)	Time (h)	Simulated GI region
1.2	302	2	Stomach
6.0	330	1	Duodenum
7.2	330	5	Lower small intestine and colon

Citation: Cheng G, An F, Zou MJ, Sun J, Hao XH, He YX. Time- and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid. World J Gastroenterol 2004; 10(12): 1769-1774
URL: https://www.wjgnet.com/1007-9327/full/v10/i12/1769.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i12.1769