Copyright
©The Author(s) 2004.
World J Gastroenterol. Jun 15, 2004; 10(12): 1740-1745
Published online Jun 15, 2004. doi: 10.3748/wjg.v10.i12.1740
Published online Jun 15, 2004. doi: 10.3748/wjg.v10.i12.1740
Table 5 Kinetics of IFN-treated gene expression profiles in 23 selected genes from HepG2 and HepG22.2.15 cells
| Accession ID | HepG22.2.15 cell lines | HepG2 cell lines | Description | ||||
| 6 h/0 h | 24 h/0 h | 48 h/0 h | 6 h/0 h | 24 h/0 h | 48 h/0 h | ||
| Interferon | |||||||
| X57352 | 3.8 | 3.1 | 2.5 | 6.5 | 8.1 | 6.4 | 1-8U gene from interferon-inducible gene family |
| X57351 | 3.4 | 2.2 | 2.2 | 4.3 | 4.4 | 4.4 | 1-8U gene from interferon-inducible gene family |
| M87503 | 2.3 | 1.7 | 1.7 | 3.2 | 2.4 | 2.6 | IFN-responsive transcription factor subunit |
| M33882 | 2.4 | 1.6 | 1.5 | 2.5 | 2.1 | 1.6 | p78 protein |
| M11810 | 9.1 | 5.7 | 4.4 | 8.4 | 7.7 | 3.9 | (2’-5’) oligo A synthetase E gene |
| L07633 | 2.0 | 1.3 | 1.5 | 2.0 | 2.7 | 1.3 | (clone 1950.2) interferon-gamma IEF SSP 5111 |
| J04164 | 6.7 | 5.0 | 2.9 | 6.4 | 7.0 | 6.5 | Interferon-inducible protein 9-27 |
| D28137 | 3.0 | 3.3 | 2.8 | 2.7 | 2.6 | 1.8 | BST-2 |
| AJ225089 | 3.9 | 1.3 | 1.1 | 1.9 | 2.1 | 1.2 | 2’-5’ oligoadenylate synthetase 59 kDa isoform |
| Kinase/Phosphate | |||||||
| U07358 | -1.3 | -1.3 | -2.5 | 1.1 | 2.4 | 1.4 | Protein kinase (zpk) |
| U02680 | -1.1 | 1.4 | -2.5 | 1.5 | 7.1 | 1.6 | Protein tyrosine kinase |
| AF032437 | -1.1 | -2.5 | -1.7 | -1.3 | -3.3 | -2.0 | Mitogen activated protein kinase activated protein kinase |
| Ligands and receptors | |||||||
| D86096 | 2.3 | 4.6 | 3.5 | 1.9 | 1.8 | 2.3 | Prostaglandin E receptor EP3 subtype |
| AF022375 | 1.8 | 1.8 | 3.2 | -1.2 | -1.1 | 1.1 | Vascular endothelial growth factor |
| Phosphatase | |||||||
| U12128 | 3.0 | 4.8 | 4.7 | -1.2 | -1.1 | -1.2 | Protein tyrosine phosphatase 1E (PTP1E) |
| Protein degradation | |||||||
| Z14977 | 2.2 | 1.2 | 1.4 | 2.7 | 1.3 | 1.6 | Major histocompatibility complex encoded |
| proteasome subunit LMP2 | |||||||
| AF061736 | 2.6 | 1.5 | 1.4 | 2.3 | 2.3 | 2.0 | Ubiquitin-conjugating enzyme RIG-B |
| Protooncogenes | |||||||
| U52969 | 1.1 | -2.0 | -1.3 | 2.2 | 1.6 | 2.1 | PEP19 (PCP4) |
| U50529 | -2.5 | -5.0 | -2.5 | 1.7 | 1.5 | 2.2 | BRCA2 region, mRNA sequence CG016 |
| Transcription factors | |||||||
| D87258 | 1.6 | 2.3 | 2.5 | 1.0 | -1.1 | -1.5 | Serin protease with IGF-binding motif |
| Viral and clathrin receptors | |||||||
| X81636 | 1.1 | 5.5 | 5.2 | -1.1 | 6.4 | -1.7 | Clathrin light chain a |
| U70321 | -1.3 | -2.0 | 1.1 | 2.0 | 1.2 | 1.6 | Herpesvirus entry mediator |
| AF079221 | 1.0 | 1.2 | 2.9 | 1.7 | 2.2 | 1.9 | BCL2/adenovirus E1B 19kDa-interacting protein 3 a |
- Citation: Wang X, Yuan ZH, Zheng LJ, Yu F, Xiong W, Liu JX, Hu GX, Li Y. Gene expression profiles in an hepatitis B virus transfected hepatoblastoma cell line and differentially regulated gene expression by interferon-α. World J Gastroenterol 2004; 10(12): 1740-1745
- URL: https://www.wjgnet.com/1007-9327/full/v10/i12/1740.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i12.1740