Reversal of multidrug resistance in drug-resistant human gastric cancer cell line SGC7901/VCR by antiprogestin drug mifepristone

Table 1 Effects of of mifepristone on intracellular VCR accumulation and rhodamine 123 retention in drug-resistant human gastric cancer cell line SGC7901/VCR and its parental counterpart SGC7901

Mifepristone	Intracellular [3H]VCR accumulation (pmol/mg protein)		Fluorescent intensity of intracellular rhodamine 123
(μmol/L)	SGC7901	SGC7901/VCR	SGC7901	SGC7901/VCR
0 (control)	3.36 ± 0.54	0.98 ± 0.20	82.36 ± 4.23	22.32 ± 3.14
1	3.41 ± 0.49	1.31 ± 0.29a	83.21 ± 5.50	28.89 ± 4.25a
5	3.54 ± 0.68	2.24 ± 0.62b	85.12 ± 4.89	45.63 ± 6.34b
10	3.65 ± 0.87	3.05 ± 0.75b	86.01 ± 6.12	68.69 ± 7.40b
20	3.84 ± 0.79	3.64 ± 0.84b	88.20 ± 6.45	82.10 ± 9.21b

^aP < 0.05,

^bP < 0.01 vs control group.