Association of differentially expressed genes with activation of mouse hepatic stellate cells by high-density cDNA mircoarray

Table 2 Part of the previously reported up-regulated genes in activation of HSC

GenBank accession number	Gene name	Ratio (Cy5/Cy3)	Potential gene function
M73741	Alpha-B2-crystallin, complete cds	155.619	Small heat shock protein gene, an early marker for HSC activation
X52046	Procollagen, type III, alpha 1	119.092	Extracellular matrix (ECM), over- expressed in hepatic fibrosis
M18194	Fibronectin mRNA	29.958	ECM, over expressed in hepatic fibrosis
J02870	Laminin receptor mRNA	6.62	ECM receptor (integrin), cell adhesion
L08115	CD9 antigen	6.094	Cell membrane glycoprotein, involved in cell activation and adhesion
U16163	Prolyl 4-hydroxylase alpha (II) - subunit mRNA, complete cds	4.555	An enzyme which is essential for the collagen synthesis in HSC
X62622	TIMP-2 mRNA for tissue inhibitor of metalloproteinase, type 2	3.732	Inhibition for ECM degradation
X04017	mRNA for cysteine-rich glycoprotein SPARC	3.435	Regulation of cell shape, adhesion, migration and proliferation
AF070470	SPARC-related protein (SRG) mRNA, complete cds	3.181	Regulation of cell shape, adhesion, migration
M21495	Cytoskeletal gamma-actin mRNA,	3.092	Relate skeleton structure of cell
AF188297	TGF-beta receptor binding protein (Trip1) mRNA, complete cds	2.976	TGF-beta mediated signaling pathway
AJ245923	alpha-tubulin 8 (Tuba 8 gene) mRNA	2.901	Relate skeleton structure of cell
AF053454	Tetraspan TM4SF (Tspan-6) mRNA complete cds,	2.896	Cell development, differentiation, motility
AF013262	Lumican gene, complete cds	2.862	Small, leucine-rich proteoglycan which involves in the regulation of collagen figril assembly
L02526	Protein kinase (MEK) mRNA	2.714	Signaling molecule in MAPK family
Y00769	mRNA for integrin beta subunit	2.521	Signaling molecular in cell adhesion, proliferation and migration