Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma

Table 3 Correlations between p-Stat3, cyclin D1, Bcl-x_L and clinicopathological parameters in colorectal carcinoma (mean ± SD)

Item	n	p-Stat3	P	cyclin D1	P	Bcl-xL	P
Gender
Male	24	2.7 ± 0.6	0.846	4.1 ± 1.6	0.913	3.7 ± 1.2	0.746
Female	21	2.5 ± 0.5		4.3 ± 1.8		3.3 ± 1.1
Age (yr)
≥ 65	22	2.8 ± 0.7	0.736	4.8 ± 2.1	0.825	3.4 ± 1.5	0.870
< 65	23	2.4 ± 0.4		3.6 ± 1.3		3.6 ± 0.8
Stage
III + IV	20	3.6 ± 0.6	0.026	5.2 ± 1.9	0.065	4.2 ± 1.3	0.235
I + II	25	1.8 ± 0.5		3.4 ± 1.5		3.1 ± 1.0
Histological
Grade
G1	12	2.3 ± 0.5	0.778	4.7 ± 1.8	0.732	3.9 ± 1.3	0.894
G2	22	2.4 ± 0.6	0.645	4.2 ± 1.4	0.627	3.3 ± 1.0	0.771
G3	11	3.4 ± 0.6	0.530	3.6 ± 2.2	0.565	3.6 ± 1.2	0.832
Node
Metastasis
Positive	27	3.8 ± 0.8	0.018	5.5 ± 1.9	0.041	4.4 ± 1.4	0.162
Negative	18	1.6 ± 0.4		3.3 ± 1.5		2.9 ± 1.0
Distant
Metastasis
M1	6	3.6 ± 0.8	0.638	5.4 ± 2.2	0.612	5.2 ± 1.6	0.324
M0	39	2.5 ± 0.5		4.0 ± 1.6		3.3 ± 1.1
Tumor Size
≥ 5 cm	22	3.0 ± 0.7	0.582	4.5 ± 1.8	0.776	3.8 ± 1.3	0.735
< 5 cm	23	2.2 ± 0.4		3.9 ± 1.6		3.2 ± 1.0

G1: well differentiated tumor, G2: moderately differentiated tumor, G3: poorly differentiated tumor, M0: no distant metastasis, M1: distant metastasis.