Changes of tumor microcirculation after transcatheter arterial chemoembolization: First pass perfusion MR imaging and Chinese ink casting in a rabbit model

Figure 4 Histological examinations of hepatic lesion before and after treatment. A: HE stain shows nidal arrangement of VX2 cells as well as micro-vessels filled with Chinese ink before treatment, magnification × 200. B: In lipiodol group, histological examina-tion shows coagulation necrosis at the center of lesion, very few micro-vessels can be seen within this zone, residual tumor cells are seen at the periphery of lesions, moreover, an intense reaction of granulation tissue is seen within this area, small dense vessels are scattered at border of the lesion, and congested sinusoids are seen in the periphery of the tumor, magnification × 200. C: Coagulation necrosis as well as large infarcts involving multiple adjacent lobules is seen in bletilla group, few vessels are seen at the border of the lesion, magnification × 200.