Transcriptional regulation of human α1(I) procollagen gene in dermal fibroblasts

Table 2 Effect of cytokines on reporter gene activity in cells transfected with pCOLH₁2.5

Cytokines		Relative value of reporter gene activity1	P value (compared to control)
Control		1.00 ± 0.15
TNFα	10 μg/L	0.43 ± 0.17	< 0.05
IFNα	1 × 105 U/L	0.62 ± 0.15	< 0.05
IFNν	1 × 105 U/L	0.60 ± 0.16	< 0.05

¹The reporter gene activity of the cells transfected with pCOLH₁2.5 was set as 1, the relative expression level of nor-malized CAT in transfected cells treated with cytokines was expressed as mean ± SD of three independent experiments.