Loss of heterozygosity on hromosome 1 in sporadic colorectal carcinoma

Table 2 Relationship between clinicopathological features and LOH of 11 loci on short arm of chromosome 1

		D1S468		D1S450		D1S2697		D1S255		D1S2797		D1S2890		D1S2841		D1S207		D1S2868		D1S206		D1S2726
		N	L	N	L	N	L	N	L	N	L	N	L	N	L	N	L	N	L	N	L	N	L
Gender	Male	18	8	20	4	13	2	19	7	20	5	21	4	20	6	31	2	15	3	17	3	19	5
	Female	15	11	21	3	12	3	24	4	26	3	27	2	26	5	32	3	24	7	16	4	29	1
Age (yr)	> 60	26	13	30	7	19	4	32	8	36	7	37	6	34	11	46	5	32	7	27	5	33	6
	≤ 60	7	6	11	0	6	1	11	3	10	1	11	0	12	0	17	0	7	3	6	2	15	0
Location	Proximal colon	12	9	12	2	13	2	14	5	19	2	22	3	21	4	24	2	13	6	11	1	20	0
	Distal Colon	7	5	10	1	4	2	12	2	8	3	11	1	9	4	17	1	13	2	8	4	13	0
	Rectum	14	5	19	4	8	1	17	4	19	3	15	2	16	3	22	2	13	2	14	2	15	61
Gross pattern	Massive	15	9	16	2	10	1	15	7	21	3	17	5	20	4	23	2	17	3	17	1	19	2
	Ulcerative	13	5	16	3	9	3	22	4	19	3	20	1	18	4	27	3	15	3	10	3	20	3
	Encroaching	5	5	9	2	6	1	6	0	6	2	11	0	8	3	13	0	7	4	6	3	9	1
Size	≥ 5 (cm)	18	8	21	5	13	1	19	8	24	4	27	2	23	4	31	1	19	5	13	5	24	3
	< 5 (cm)	15	11	20	2	12	4	24	3	22	4	21	4	23	7	32	4	20	5	20	2	24	3
LN metastasis	LN (+)	24	10	26	5	17	4	29	4	28	6	31	5	26	9	38	5	22	8	20	5	28	4
	LN (-)	9	9	15	2	8	1	14	7	18	2	17	1	20	2	25	0	17	2	13	2	20	2
Differentiation	Well	8	7	14	1	5	1	10	3	20	1	15	0	12	4	16	2	13	2	14	3	18	0
	Moderately	16	10	19	5	12	4	21	5	14	7	19	5	22	5	31	3	16	5	13	2	18	6
	Poorly	3	0	4	1	2	0	5	0	4	0	5	0	2	0	6	0	3	1	0	2	5	0
	Mucinous	6	2	4	0	6	0	7	3	8	0	9	1	10	2	10	0	7	2	6	0	7	0
Dukes stage	A	3	3	4	0	1	0	4	1	3	2	4	0	7	0	7	0	5	0	2	1	5	0
	B	6	6	11	2	7	1	10	6	15	0	13	1	13	2	18	0	12	2	11	1	15	2
	C	17	8	20	3	11	2	21	3	20	5	23	5	18	7	26	5	16	7	18	3	20	4
	D	7	2	6	2	6	2	8	1	8	1	8	0	8	2	12	0	6	1	2	2	8	0

¹P = 0.002, LOH frequency of rectal cancer vs colon cancer.