Expression and altered subcellular localization of the cyclin-dependent kinase inhibitor p27Kip1 in hepatocellular carcinoma

Table 2 Relationship among p27, PCNA, and cytoplasmic p27staining with clinicopathologic features

Parameters	p27 LI (%)	P	PCNA LI (%)	P	Cytoplasmic p27 LI (%)	P
Gross type
Massive	20.5 ± 13.1	0.037	46.4 ± 13.4	0.249	25.9 ± 18.9	0.221
Nodular	35.7 ± 23.4		52.3 ± 14.7		17.9 ± 17.3
Tumor size
≤ 5 cm	23.8 ± 14.4	0.645	38.1 ± 10.7	0.047	27.0 ± 24.1	0.481
> 5 cm	28.4 ± 20.9		51.7 ± 13.9		20.6 ± 17.4
Cellular differentiation
Well or moderate	29.7 ± 21.4	0.438	45.7 ± 13.8	0.031	23.2 ± 18.0	0.498
Poor	23.8 ± 17.1		56.9 ± 12.6		18.6 ± 19.1
Degree of invasion
T1 + T2	32.6 ± 23.3	0.285	51.1 ± 14.7	0.64	33.0 ± 22.3	0.019
T3 + T4	24.7 ± 17.5		48.6 ± 14.4		14.8 ± 11.1
Stage
I + II	33.6 ± 25.6	0.261	48.0 ± 12.9	0.688	35.3 ± 23.9	0.029
III + IV	24.9 ± 16.7		50.2 ± 15.0		15.4 ± 10.7
Infiltration
Present	18.3 ± 18.8	0.036	44.4 ± 12.3	0.117	19.0 ± 18.3	0.536
Absent	33.3 ± 18.7		52.6 ± 14.7		23.2 ± 18.5
Lymphocyte metastasis
With	25.5 ± 2.6	0.565	56.0 ± 14.9	0.339	16.0 ± 10.6	0.518
Without	27.9 ± 21.3		48.6 ± 14.2		22.4 ± 19.1
Portal invasion
Present	14.3 ± 12.7	0.229	58.3 ± 12.0	0.267	13.0 ± 11.8	0.398
Absent	29.1 ± 20.1		48.6 ± 14.3		22.5 ± 18.7