Protective role of metallothionein (I/II) against pathological damage and apoptosis induced by dimethylarsinic acid

Figure 5 Apoptosis in livers of MT^+/+ and MT^-/- mice detected by TUNEL twenty-four hours after oral DMAA treatment. A: Typical apoptotic cells in the liver of MT^-/- mice at a dose of 188 mg/kg body weight. Brown staining indicates apoptotic cells. The bar is 20 μm. B. AI in the livers. All values were ex-pressed as ^-χ±s. ANOVA with subsequent post hoc’s test was performed for comparison of AI. ^{a, b}Significant difference at P < 0.05, P < 0.01 when compared with the corresponding control group. ^c,dSignificant difference at P < 0.05, P < 0.01 when com-pared with the dose-matched MT^-/- mice group.