Protective role of metallothionein (I/II) against pathological damage and apoptosis induced by dimethylarsinic acid

Figure 4 Apoptosis in lungs of MT^+/+ and MT^-/- mice detected by TUNEL twenty-four hours after oral DMAA treatment. A: Typical apoptotic cells in alveolar area of MT^-/- mice at a dose of 188 mg/kg body weight. Brown staining indicates the apoptotic cells. The bar is 20 μm. B: Typical apoptotic cells in bronchial area of MT^-/- mice at a dose of 188 mg/kg body weight. Brown staining indicates apoptotic cells. The bar is 20 μm. C: AI in alveolar area. D: AI in bronchial area. All the values were expressed as ^-χ±s. ANOVA with subsequent post hoc’s test was performed for comparison of AI. ^a,bSignificant difference at P < 0.05, P < 0.01 when compared with the corresponding control group. ^c,dSignificant difference at P < 0.05, P < 0.01 when com-pared with the dose-matched MT^-/- mice group.