Potential role of p53 mutation in chemical hepatocarcinogenesis of rats

Figure 5 Direct sequencing of p53 exons 6/7 and 8. A: GAG to AAG transition mutation (red box) at codon 202 of exon 6/7 was seen in prehepatocarcinoma foci at 6 weeks. C: Four hepatocarcinoma foci with GAC to AAC transition mutation (red box) at codon 206 formed one of the mutation hot spots. E: GGG to TGG transversion mutation (red box) at codon 300 of exon 8 in hepatocarcinoma foci. B, D and F were normal sequence.