Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial

Figure 5 TIL responses in surgical specimens in treatment and control groups. In control group, there was a progressive de-crease in TIL responses with increase of TNM staging. On the other hand, the treatment group showed a steady increase in TIL responses after CIM treatment for 1 wk. The differences in TIL response rates were statistically significant between treat-ment and control groups for TNM stages III and IV diseases (^aP < 0.05 and ^bP < 0.01, respectively, Fisher’s exact test).