Clinical application of 5-HTa-3R antagonist tropisetron in chemotherapy patients

Table 1 Emetogenic potential of chemotherapeutic agents; 5 = highest, 1 = lowest[1]

Grade 5		Grade 4		Grade 3		Grade 2		Grade 1
Drug	Dose (mg/m2)	Drug	Dose (mg/m2)	Drug	Dose (mg/m2)	Drug	Dose (mg/m2)	Drug
Cisplatin	> 100	Cisplatin	50-100	Dactinomycin	> 0.3	Dactinomycin	< 0.3	Amsacrine
				Carboplatine	> 150	Altreamine		Asparaginase
				Carmustine	> 75	Carboplatin	≤ 150	Bleomycin
				Chlormethine	> 6	Carmustine	≤ 75	Etoposide
				CyClo-		Chlormethine	≤ 6	Fluorouracil
				Phosphamide	> 50	Cisplatin	≤ 50	Mercaptopurine
				Cytarabine	> 1000	Cyclo		Methotrexate
				Dacarbazine	> 100	Phosphamide	≤ 50	Mitomycin
				Daunorubicin	> 45	Cytarabine	≤ 1000	Mitoxantrone
				Doxorubicin	> 45	Dacarbazine	≤ 100	Procarbazine
				Epirubicin	> 75	Daunorubicin	≤ 45	Teniposide
				Ifosfamide	> 1000	Doxorubicin	≤ 45	Thioguanine
						Epirubicin	≤ 75	Vinorelbine
						Fotemustine		Vinblastine
						Ifosfamide	≤ 1000	Vincristine
								Vindesine

Abbreviations: A agents are classified as Grade 1 irrespective of dose.