Loss of heterozygosity at adenomatous polyposis coli, mutation in colorectal cancer and deleted in colorectal cancer genetic loci in colorectal cancers

Table 3 Correlation between loss of heterozygosity at the adenomatous polyposis coli, mutation in colorectal cancer and deleted in colorectal cancer genes and clinicopathological parameters of colorectal cancers

Group	LOH/ Informative (%)
	APC	MCC	DCC
Grade (differentiation)
Well/Moderate	4/14 (28.6)	4/12 (33.3)	8/20 (40.0)
Low differentiated	2/8 (25.0)	3/6 (50.0)	10/14 (71.4)
Mucoid	1/3 (33.3)	1/4 (25.0)	3/4 (75.0)
Size
≤ 3 cm	3/8 (37.5)	4/12 (33.3)	7/15 (46.6)
> 3 cm	4/17 (23.5)	4/10 (40.0)	14/23 (60.9)
Serosal invasion
Negative	5/16 (37.5)	4/14 (28.5)	10/23 (43.4)
Positive	2/9 (22.2)	4/9 (50.0)	11/15 (73.3)
Lymph-node metastasis
Negative	4/16 (25.0)	5/14 (35.7)	9/23 (39.1)
Positive	3/9 (33.3)	3/8 (37.5)	12/15 (80.0)a
Dukes' stages
Stages I and II	4/14 (28.5)	4/10 (40.0)	6/17 (35.3)
Stages III and IV	3/11 (27.3)	4/12 (33.3)	15/21 (71.4)

^aP < 0.05. LOH: Loss of heterozygosity; APC: Adenomatous polyposis coli; MCC: Mutation in colorectal cancer; DCC: Deleted in colorectal cancer