Research progress on the mitochondrial mechanism of age-related non-alcoholic fatty liver

doi:10.3748/wjg.v29.i13.1982

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2023; 29(13): 1982-1993
Published online Apr 7, 2023. doi: 10.3748/wjg.v29.i13.1982

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Figure 1 Enzymatic regulation of fatty acid aerobic oxidation. SCFA: Short-chain-fatty acids; CPT1: Carnitine palmitoyltransferase-1; CPT2: Carnitine palmitoyltransferase-2; LCFA: Long-chain fatty acids; VLDL: Very low density lipoprotein; ACSL: Long-chain acyl-CoA synthetase; TCA: Tricarboxylic acid; ACS: Acyl-CoA synthetase; ACC: Acetyl-CoA carboxylase; ETC: Electronic respiratory chain; FASN: Fatty acid synthase.

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Figure 2 Mitochondrial depolarization activates the PINK1/Parkin pathway to mediate mitophagy. NIX: Nip3-like protein X; BNIP3: Bcl-219 kDa interacting protein.

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Figure 3 Mitochondrial depolarization activates the PINK1/Parkin pathway to mediate mitophagy. FFA: Free fatty acid; ROS: Reactive oxygen species; TCA: Tricarboxylic acid; mtDNA: Mitochondrial DNA; ETC: Electronic respiratory chain.

Citation: Wang D, Ji DC, Yu CY, Wu DN, Qi L. Research progress on the mitochondrial mechanism of age-related non-alcoholic fatty liver. World J Gastroenterol 2023; 29(13): 1982-1993
URL: https://www.wjgnet.com/1007-9327/full/v29/i13/1982.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i13.1982