Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients

Figure 1 Graphical representations of difference in methylated septin 9 Ct values or proportion of patients between different groups. A: Methylated septin 9 (mSEPT9) Ct values in tumor group and normal group; B: Proportion of patients with positive and negative mSEPT9 in tumor group and normal group; C: Proportion of patients older than 50 and aged 50 or younger in positive group and negative group. The statistical significance for difference of means is shown in P values, t-test, or χ² test. mSEPT9: Methylated septin 9.

Figure 2 Graphical representations of the proportion of patients with positive and negative methylated septin 9 with different tumor status. A: Union for International Cancer Control stages; B: Primary tumor categories; C: Regional node categories; D: Distant metastasis categories. The statistical significance for difference of means is shown in P values and χ² test).

Figure 3 Graphical representations of methylated septin 9 Ct values in different tumor status. A: Union for International Cancer Control stages; B: Primary tumor categories; C: Regional node categories; D: Distant metastasis categories. The statistical significance for difference of means is shown in P values and t-test. mSEPT9: Methylated septin 9.

Figure 4 Kaplan-Meier univariate survival curves according to methylated septin 9 status. A: Progression-free survival time; B: Overall survival. The statistical significance for difference of means shown in P values and Kaplan-Meier univariate analysis. mSEPT: Methylated septin; CI: Confidence interval.

Figure 5 Venn diagram of eight co-upregulated methylated septin 9 sites and one co-downregulated methylated septin 9 site in colon and rectum adenocarcinoma. “Rectum-low” and “Rectum-high” represented sites that showed low or high expression in rectum adenocarcinoma, and “Colon-low” and “Colon-high” represented sites that showed low or high expression in colon adenocarcinoma. Eight co-upregulated methylated septin 9 (mSEPT9) sites also showed mSEPT9 expression fold of rectum/ colon adenocarcinoma compared to normal subjects and corresponding P value. mSEPT: Methylated septin.