Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer

Figure 1 MAPK, Wnt, Notch and PI3K/Akt signaling is involved in acinar-to-ductal metaplasia. The potential therapies are shown in red (retinoic acid is not shown). EGF: Epidermal growth factor; TGFα: Transforming growth factor alpha; MMP7: Matrix metalloproteinase 7.

Figure 2 Development of pancreatic intraepithelial neoplasia pancreatic ductal adenocarcinoma from acinar cells through acinar-to-ductal metaplasia. During ADM, cells in each state have their own morphology and protein expression pattern. ADM: Acinar-to-ductal metaplasia.