5-ASA colonic mucosal concentrations resulting from different pharmaceutical formulations in ulcerative colitis

Figure 1 Distribution of 5-aminosalicylic acid mucosal concentrations in the sigmoid colon in patients receiving oral 5-aminosalicylic acid either pH-dependent release formulations, time-dependent release formulations or prodrugs. 5-ASA: 5-aminosalicylic acid.

Figure 2 5-aminosalicylic acid mucosal concentrations in the sigmoid colon. A: In patients receiving oral 5-aminosalicylic acid (5-ASA) pH-dependent release formulations according to endoscopic and histological grading of disease; B: In patients receiving 5-ASA pH-dependent release formulations on oral plus topical treatment or oral therapy alone.