Malakoplakia of the esophagus caused by human papillomavirus infection

Figure 1 Soft yellow nodules protruding into the esophageal cavity. A: Gastroscopy presentation: soft yellow nodules protruding into the esophageal cavity; B: Endoscopic ultrasonography: a space-occupying lesion (8.1 mm × 5.1 mm) in the substratum sized 8.1 mm × 5.1 mm (dotted lines).

Figure 2 Michaelis-Gutmann bodies. A: Basophilic laminated inclusions in the cytoplasm (hematoxylin and eosin, ×200); B: Periodic acid-Schiff: targetoid appearance with a dense central core (×400); C: CD68 positivity by immunohistochemistry (×400); D: Esophageal squamous epithelium positive for human papillomavirus by immunohistochemistry, halo-shaped cells (×200).