Infantile hepatic hemangioendothelioma: A clinicopathologic study in a Chinese population

Figure 1 Contrast-enhanced arterial phase computed tomography. A: Solitary hypoattenuated mass with a well-defined contour containing calcifications in a fine-speckled pattern (case 7); B: Diffuse polycystic changes with variable sizes and an ill-defined region in both hepatic lobes (case 5).

Figure 2 Appearance of a solitary mass. A: A solitary mass in the liver from an autopsy case (case 12); B: Cut surface of a solitary mass in liver demonstrating homogeneous, red-brown and partially ill-circumscribed tumor (case 8).

Figure 3 Histopathological features of type I lesions. A: Mature vascular channels (case 7, HE, × 60); B: Plump endothelial cells with a bland cytological appearance (case 7, HE, × 200); C: Cavernous structures (case 7, HE, × 100); D: Calcification foci (case 7, HE, × 100).

Figure 4 Histopathological features of type II lesions. A: Multifocal nodule without encapsulation. Tumor nodules intermixed with the hepatic plate (case 5, HE, × 60); B: Anastomosing vascular structures (case 8, HE, × 300); C: A papillary structure with atypical endothelial cells (case 5, HE, × 400); D: Hyperchromatic and pleomorphic endothelial cells with mitotic cells (case 8, HE, × 400); E: Activated mitotic cells in a dense area (case 8, HE, × 400); F: Eosinophilic granulocytes were the predominant inflammatory component in one case (case 5, HE, × 400).

Figure 5 Immunohistochemical results. A: Expression of CD34 in endothelial cells in a type I lesion (case 7, immunohistochemistry, × 200); B: CD34 expression in endothelial cells in a type II lesion (case 8, immunohistochemistry, × 200).