COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?

doi:10.3748/wjg.v16.i12.1430

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Mar 28, 2010 (publication date) through Jun 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2010; 16(12): 1430-1435
Published online Mar 28, 2010. doi: 10.3748/wjg.v16.i12.1430

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Figure 1 Schematic representation of the effects of transgenic expression of cyclooxygenase 2 (COX-2) in hepatocytes. The transgene protects against acute liver injury, but fails to alter the response to hepatocarcinogens, such as diethylnitrosamine (DEN). KC: Kupffer cell; HC: Hepatocyte; EC: Endothelial cell; HCC: Hepatocellular carcinoma; WT: Wild type; TG: COX-2 transgenic mice.

Citation: Martín-Sanz P, Mayoral R, Casado M, Boscá L. COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models? World J Gastroenterol 2010; 16(12): 1430-1435
URL: https://www.wjgnet.com/1007-9327/full/v16/i12/1430.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i12.1430