Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury

Figure 1 Structure of S-adenosyl-L-methionine (SAM), S-adenosylhomocysteine (SAH), and methionine and hepatic methionine metabolism. BHMT: Betaine homocysteine methyltransferase; CBS: Cystathionine β-synthase; GSH: Glutathione; MAT: Methionine adenosyltransferase; MS: Methionine synthase; MT: Methyltransferase; SAHH: SAH hydrolase; SAMDC: SAM decarboxylase.

Figure 2 Proposed mechanism by which SAM protects against CYP2e1-hepatotoxicity. ROS: Reactive oxygen species; CYP: Cytochrome P450; NF-κB: Nuclear factor κB; Nrf2: Nuclear factor erythroid 2-related factor 2.