Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats

Figure 1 Histopathological changes in pancreatic and hepatic specimens. A: Obvious acinar cell degeneration, edema and inflammation in caerulein group. B: Acinar cell degeneration and fat necrosis in caerulein group. C: Hepatocyte necrosis, vascular congestion, sinusoidal dilatation and inflammatory infiltration in caerulein group. D: Prominent intracellular vacuolization in hepatic specimens from caerulein group.

Figure 2 Histopathological evidence of pancreatic and hepatic damage. A: Normal histological appearance except for minimal infiltration in caerulein + melatonin group. B: Normal histological appearance except for minimal edema in caerulein + L(+)-ascorbic acid + N-acetyl cysteine group. C:Normal histological appearance in caerulein + melatonin group. D: Two small areas of necrosis and cell infiltration in caerulein + L(+) - ascorbic acid + N - acetyl cysteine group.