Colon-specific drug delivery systems based on cyclodextrin prodrugs: In vivo evaluation of 5-aminosalicylic acid from its cyclodextrin conjugates

Figure 1 Concentration of 5-ASA and Ac-5-ASA in serum (◆), urine (■), feces (○), liver homogenates (△), stomach contents (◇), small intestinal contents (▲), cecal contents (□), colonic contents (×) after the oral administration of 50 mg/kg 5-ASA or α-CyD-5-ASA (equivalent to 50 mg/kg 5-ASA) to rats. A: Concentration of 5-ASA after oral administration of 5-ASA; B: concentration of Ac-5-ASA after oral administration of 5-ASA; C: concentration of 5-ASA after oral administration of 10 α-CyD-5-ASA; D: concentration of Ac-5-ASA after oral administration of α-CyD-5-ASA.