Antitumor effects of vaccine consisting of dendritic cells pulsed with tumor RNA from gastric cancer

Figure 1 Tumor growth curve. Control group mice (n = 12) were inoculated sc with 5 × 10⁵ MFC gastric cancer cells without any immunization. UDC group mice (n = 10) were immunized twice with unpulsed DCS followed by inoculation sc with 5 × 10⁵ MFC gastric cancer cells. RNA/DC group mice (n = 12) were immu-nized twice with RNA pulsed DCs followed by inoculation s c with 5 × 10⁵ MFC gastric cancer cells.

Figure 2 Cytotoxicity of NK cells and CTL. PBNK: NK cell activity in PBL, Sp-NK: NK cell activity in splenocytes, CTL-MFC: CTL activity to lyses MFC murine gastric cancer cells.

Figure 3 Serum IL-12 p40 levels in three groups of mice three weeks after tumor challenge.