Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism

doi:10.3748/wjg.v18.i25.3207

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2012; 18(25): 3207-3214
Published online Jul 7, 2012. doi: 10.3748/wjg.v18.i25.3207

Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism

Talita Cavalcante Morais, Synara Cavalcante Lopes, Karine Maria Martins Bezerra Carvalho, Bruno Rodrigues Arruda, Francisco Thiago Correia de Souza, Maria Teresa Salles Trevisan, Vietla Satyanarayana Rao, Flávia Almeida Santos, Department of Physiology and Pharmacology, Brazilian Semi-Arid Institute of Biomedicine, Faculty of Medicine, Federal University of Ceará, Fortaleza 60430-270, Brazil

Karine Maria Martins Bezerra Carvalho, Post-Graduate Programme in Medical Sciences, Faculty of Medicine, Federal University of Ceará, Fortaleza 60430-140, Brazil

Francisco Thiago Correia de Souza, Maria Teresa Salles Trevisan, Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza 60451-970, Brazil

Author contributions: Morais TC designed the research; Morais TC, Lopes SC, Carvalho KMMB and Arruda BR contributed to the experimental part; Rao VS and Santos FA wrote the paper; de Souza FTC and Trevisan MTS isolated the compound mangiferin.

Supported by National Council of Technological and Scientific Development (CNPq); Ceará Foundation for the Support of Scientific and Technological Development of the Ceará State (FUNCAP), Brazil

Correspondence to: Vietla Satyanarayana Rao, Associate Professor of Pharmacology, Department of Physiology and Pharmacology, Brazilian Semi-Arid Institute of Biomedicine, Faculty of Medicine, Federal University of Ceará, Rua Cel. Nunes de Melo, 1127, Rodolfo Teófilo, Fortaleza 60430-270, Brazil. viet_rao@yahoo.com.br

Telephone: +55-85-33668341 Fax: +55-85-33668333

Received: November 30, 2011
Revised: April 25, 2012
Accepted: May 6, 2012
Published online: July 7, 2012

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